ACTIVE
Grants, Contracts, and Cooperative Agreements
1R01 HL127071 (Fadel)
NIH NHLBI
04/01/16 – 03/31/20
$296,657
0.52 calendar
Role as Co-I, The goal of this study isto determine the specific mechanisms leading to hyperactivity of the sympathetic system in CKD patients. Due to the participation of the musculoskeletal system and potential new biomarkers, I am contributing as a Co-Investigator as well as my laboratory.
2-P01 AG039355-A-1 (Bonewald, Brotto, Dallas, Johnson)
NIH NIA
Osteocyte Regulation of Bone/Muscle with Age
10/01/18 – 09/30/23
$277,127
3.0 calendar
Project 2; Project Director: The goal of this program project grant is to investigate the biochemical signaling mechanisms regulating specific factors that influence the health and function of each tissue vice-versa during aging using cell and via the Wnt/β-catenin pathway during aging.
R01 AG056504-01A1 (MPI: Brotto, Weisleder)
NIH, National Institutes of Aging (NIA)
Regulation of Store-Operated Calcium Entry during Muscle Aging
7/1/2018 – 6/30/2023
$388,000
1.76 calendar
The goal of these studies is to determine the specific roles of MG29 in skeletal muscle during aging.
1R01AG060341-01 (MPI: Brotto, Cardozo)
NIH, NIA
Loss of Numb in Muscle Dysfunction in Aging
09/01/18 – 08/30/23
$288,421
1.20 calendar
The goal of this proposal is to investigate the role of the Numb gene/protein in EC muscle aging through its effects on regulation of the EC coupling process.
2-R01NS105621-01-A1 (Zhou, Brotto)
NIH, National Institutes of Neurological Disorders
Preserving mitochondria function for ALS progression
10/1/2018 – 09/30/23
$459,000
1.20 calendar
Goal is to discover new pre-clinical ALS treatments by studying new mechanisms of crosstalk between the gut and skeletal muscles.
1R01DK119066-01A1 (MPI: Brotto, Tipparaju)
NIH, National Institutes of Diabetes, Kidney
Protecting the diabetic skeletal muscle by Nampt activation
04/01/19 – 03/31/24
$284,000
1.2 calendar
The goal of this project is to test and decipher muscle function from diabetic mice and underlying molecular machinery that leads to muscle injury and to investigate the role of Nampt in this process and as a potential therapeutic target.
Brotto Research Lab Startup (Brotto)
UTA/College of Nursing & Health Innovation
09/01/15 – Present
Current: $184,000
The goal of this startup was for my lab to relocate from the University of Missouri to UTA and for me to establish the Bone-Muscle Collaborative Sciences, which has now become the Bone-Muscle Research Center.
STARs (Science and Technology Acquisition and Retention) (Brotto)
University of Texas System
$500,000 (spent out)
The goal of this funding mechanism is to attract and retain high caliper faculty at the UT system, particularly those important for the Strategic Plan of the system. This award was solely used for the purchase of high-end equipment for the Brotto Muscle Research Lab and the Bone-Muscle Research Center.
George & Mary Hazel Jay Endowment (Brotto)
University of Texas/College of Nursing & Health Innovation
09/01/15 – Present
$30,000/Yearly
This yearly endowment fund provides diversified support to my research program at UTA. I usually use to expand NIH support.
Appointments / Affiliations (Outside of University)
University of Missouri Kansas City (UMKC)
Adjunct (Collaboration on a NIH P01)
0 months
USA
UT-Southwestern
Adjunct (To assist with collaborations)
0 months
USA
University of Piedmont, Italy
Advisor to the Graduate Program
(Mostly online, or when attending European meetings)
0.05 months
Italy
In-kind Lab or Office Space, Equipment, Supplies
None
Materials Received that are Not Freely Available to Others
(e.g. biologics, chemicals, model systems, technology etc. that are not available to other researchers on the same basis as received by senior/key personnel)
UMKC, knockout mice, $2,000
Ohio State University, knock out mice $1,000
USA
USA
Foreign Collaborations / Foreign Components
(Foreign components must be preapproved by NIH)
Dr. Gustavo Duque, Melbourne University
Australia
Collaboration involves discussing ideas around research area. NIH Program Officer suggested that we should collaborate on certain common projects.
Dr. David Karasik, Bar-Ilan University, University.
Collaboration involves projects in the areas of GWAS exploring pleiotropic genes with functions in bone and muscle. Our studies had helped in the development of new animal and Zebrafish models.
Dr. Marco Invernizzi, Piedmont University.
Itlay
He invited me to become a mentor to the graduate program and we are discussing some potential collaborations.
Dr. Yuanhui Hu, Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences
China
Collaboration involves discussion about analyzing sample of unique populations in China that seem to maintain levels of muscle mass and force during aging. I sought permission from UTA and discussed with NIH the onset of these conversations.
Dr. Hanming Cui, Center for the Development of Chinese Medicine
China
Collaboration involves discussion about testing potential natural products for treatment of musculoskeletal disorders. I sought permission from UTA and discussed with NIH the onset of these conversations.
Visiting Scholars
(Staff/Scientists/Post-docs/Students independently funded by another country in whole or in part)
Lab personnel who have financial support from a foreign entity through salary, stipend, receipt of living or travel expenses, names do not need to be listed and it should be only scholars currently in the labsince this active support.
Ask foreign entity for funding amount.
Research Scientist (M.Sc.) (one)
6/1/19 – 5/31/20
$0 (None; All support from US)
China
OVERLAP (Scientific, Financial and Effort Commitment)
None