This is an essential cellular approach to measure the process through, which satellite cells or myoblasts fuse to become mature myotubes or muscle cells. We are able to conduct these studies in cell lines, in primary myoblasts from mice, and in primary myoblasts from humans during aging and with different pathologies, allowing us to infer important insights about muscle development and muscle injury and repair and aging in vitro.
Crosstalk between MLO-Y4 osteocytes and C2C12 muscle cells is mediated by the Wnt/β-catenin pathway